Cell migration is the cornerstone of many biological phenomena such as cancer metastasis, immune response or organogenesis. Therefore, understanding the regulation mechanisms that define directional cell migration will allow elucidating the fundamental processes involved in normal and pathological conditions. Cell migration is a complex phenomenon during which cells can show different phenotypes or migration modes according to its interactions with the extracellular matrix and its neighbor cells. Although many contributions have been made during the last few years, there are still open crucial aspects to understand cell-cell and cell-matrix communication.
During this conference we plan to discuss important physical and mechanical questions related to both single and collective cell migration, to identify how and where the numerical models can help to decipher the main principles of these mechanobiological phenomena.
Among the interesting and challenging aspects we would like to address during the colloquium we can cite:
- The cell behavior during single and collective migration, in particular the mechanical processes involved
- The interaction between the cell and its environment which may include neighbor cells or the extracellular matrix and how the mechanical properties (i.e. matrix stiffness) may affect the cell response
- The role of cell mechanical properties and of adhesion forces during migration in different configurations (i.e. confinement, durotaxis, etc…)
- The different strategies that the cell may adopt according to its dimensionality (i.e. 1D vs 2D vs 3D)
- The role of the nucleus as the biggest and stiffest organelle of the cell during confined migration and migration over microstructured substrates
- The integration and dialogue between in-vitro/in-vivo experiments and numerical modelling
The conference intends to bring together researchers from complementary fields including biology, medicine, mathematics, physics and mechanics.
It will take place over three days and will include 2 to 4 keynotes and a series of short talks as well as poster sessions.